75571-32-3Relevant academic research and scientific papers
Silver-Catalyzed Ring-Opening Strategy for the Synthesis of β- and γ-Fluorinated Ketones
Zhao, Huijun,Fan, Xuefeng,Yu, Jiajia,Zhu, Chen
, p. 3490 - 3493 (2015)
A regioselective synthesis of β- and γ-fluorinated ketones via silver-catalyzed ring opening is described. A variety of β- and γ-fluorinated ketones are efficiently prepared, respectively, from tertiary cyclopropanol and cyclobutanol precursors, providing a straightforward approach for the introduction of a fluorine atom into complex molecules. Preliminary mechanistic studies suggest that a radical-mediated sequential C-C bond cleavage and C-F bond formation pathway is involved.
C-C Bond Fluorination via Manganese Catalysis
Lu, Yen-Chu,West, Julian G.
, p. 12721 - 12728 (2021/10/21)
β- and γ-fluorinated ketones are desirable moieties in building blocks for bioactive molecules. Recent progress in installing this functionality has centered around ring-opening carbon-carbon bond cleavage/fluorination of strained cycloalkanols, either us
Rapid and scalable synthesis of fluoroketonesviacerium-mediated C-C bond cleavage
Lu, Yen-Chu,Jordan, Helen M.,West, Julian G.
supporting information, p. 1871 - 1874 (2021/03/02)
Ketones with remote fluorination are an important motif in the synthesis of bioactive molecules. Here we demonstrate that ceric ammonium nitrate (CAN) is able to produce this functionality under incredibly mild conditions and short reaction times (30 min)
Piperazino-anilido compounds
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, (2008/06/13)
Novel 1,4-disubstituted piperazine compounds and pharmaceutical compositions incorporating such compounds in conjunction with orally, parenterally or rectally administrable pharmaceutically acceptable carriers are disclosed. These compounds have coronary vasodilating properties. Also disclosed are processes for preparing these compounds, and novel intermediate compounds used in such processes.
