75572-80-4

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 4392-24-9 Cinnamyl bromide 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 22105-09-5 4‐hydroxycoumarin 
• 103-54-8 cinnamyl acetate 
• 166337-55-9 4-(Z-3-phenyl-2-propenyloxy)-coumarin 
• 75572-71-3 4-Cinnamyloxycoumarin 
• 109797-47-9 4-Acetoxy-3-(1-phenylallyl)coumarin 

Downstream Products

• 109797-49-1 trans-2-methyl-3-phenyl-2,3-dihydrofuro<3,2-c><1>benzopyran-2(H)-one 
• 109797-49-1 cis-2-methyl-3-phenyl-2,3-dihydrofuro<3,2-c><1>benzopyran-2(H)-one 
• 75572-78-0 3-methyl-2-phenyl-2,3-dihydro-4H-furo[3,2-c]chromen-4-one 

Relevant academic research and scientific papers

Direct enantioselective allylic substitution of 4-hydroxycoumarin derivatives with branched allylic alcohols: Via iridium catalysis

A highly efficient direct asymmetric allylic substitution (AAS) reaction of 4-hydroxycoumarin derivatives with branched allylic alcohols was realized by combining a chiral iridium complex catalyst with a Lewis acid under mild reaction conditions, delivering various chiral allylation products in remarkably high yields and excellent enantioselectivities. The salient features of this transformation include mild reaction conditions, general substrate scope, good functional group tolerance, high yields, excellent selectivities and easy scale-up. Furthermore, the obtained products can be readily transformed into several kinds of bioactive compounds.

In(OTf)3-catalysed easy access to dihydropyranocoumarin and dihydropyranochromone derivatives

We developed an easy, In(OTf)3-catalysed, regioselective and generalizable method, for allylation/cyclization of β-ketolactone-type heterocyclic compounds. This reaction is proposed to proceed one-pot, through a Friedel-Crafts C-allylation followed by cyclization. This process represents a green synthetic method, as AcOH is the only isolated byproduct. We propose here, a protocol applicable for the construction of biologically active dihydropyranocoumarin and dihydropyranochromone derivatives.

4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. STR1 Wherein R 10 and R 20 taken together are: STR2

Further Investigation on -Sigmatropic Rearrangement of Allyl Ethers of 4-Hydroxycoumarin

Pyrolytic -sigmatropic rearrangements of 4-(2-methyl-allyloxy)coumarin (7), 4-(cyclohex-2-enyloxy)coumarin (8) and 4-cinnamyloxycoumarin (11) afford 4-hydroxy-3-(2-methylallyl)coumarin (9), 3-(cyclohex-2-enyl)-4-hydroxycoumarin (10) and trans-2,3-dih