755753-54-9

Upstream product

• 719308-09-5 (2S)-2-benzyloxycarbonylamino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester 
• 4668-43-3 (S)-3-(benzyloxycarbonylamino)-4-ethoxy-4-oxobutanoic acid 
• 719307-95-6 (2S)-2-benzyloxycarbonylamino-N-(2-oxo-2-phenyl-ethyl)-succinamic acid ethyl ester 

Downstream Products

• 719308-31-3 (2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid ethyl ester hydrochloride 
• 719308-63-1 (2R)-2-{1-[(1S)-1-ethoxycarbonyl-2-(5-phenyloxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid ter-butyl ester 
• 719308-59-5 C₃₀H₄₂N₂O₇ 
• 719307-46-7 C₂₆H₃₄N₂O₆ 
• 719307-45-6 C₂₆H₃₄N₂O₇ 
• 719307-70-7 (2R)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-pentanoic acid 
• 719307-81-0 (2S)-2-{1-[(1S)-1-carboxy-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric acid 
• 719307-48-9 (2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid 
• 719308-47-1 (2S)-2-amino-3-(5-phenyl-oxazol-2-yl)-propionic acid isobutyl ester hydrochloride 
• 872221-56-2 potassium-(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyrate 

Relevant academic research and scientific papers

Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2′ subsite within NEP. Structural optimisation led to

NEUTRAL ENDOPEPTIDASE INHIBITOR POLYMORPH

Disclosed are (2S)-2-{1-[(1S)-1-Isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric, Potassium-(2S)-2-{1-[(1S)-1-Isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyrate,