7558-79-4

Basic information

• Product Name: Sodium Phosphate, Dibasic
• Synonyms: DIBASIC SODIUM PHOSPHATE;DINATRII PHOSPHAS DIHYDRICUS;DINATRII PHOSPHAS ANHYDRICUS;DISODIUM PHOSHATE;DISODIUM PHOSPHATE DIHYDRATE;DISODIUM PHOSPHATE;DI-SODIUM HYDROGEN ORTHOPHOSPHATE;DI-SODIUM HYDROGEN ORTHOPHOSPHATE 2H2O
• CAS NO: 7558-79-4
• Molecular Formula: HNa2O4P
• Molecular Weight: 141.96
• EINECS: 231-448-7
• Product Categories: Inorganics;Chemistry;metal phosphate compound;NULL;Food Additives
• Mol File: 7558-79-4.mol

Chemical Properties

• Melting Point: 243-245 °C
• Boiling Point: 158oC at 760 mmHg
• Appearance: White/powder
• Density: 1.064 g/mL at 20 °C
• Vapor Density: 4.9 (vs air)
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: Store at RT.
• Solubility: H2O: 0.5 M at 20 °C, clear, colorless
• PKA: (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
• Water Solubility: >=10 g/100 mL at 20 ºC
• Sensitive: Hygroscopic
• Stability: Stable. Incompatible with strong acids. Hygroscopic.
• Merck: 14,8659
• CAS DataBase Reference: Sodium Phosphate, Dibasic(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium Phosphate, Dibasic(7558-79-4)
• EPA Substance Registry System: Sodium Phosphate, Dibasic(7558-79-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: WC4500000
• F: 3
• TSCA: Yes
• Hazardous Substances Data: 7558-79-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Analysis:
Sodium Phosphate, Dibasic is used as a laboratory reagent and a buffer for chemical analysis, providing stability and accuracy in various experiments.
Used in Manufacturing:
Sodium Phosphate, Dibasic is used in the manufacturing of ceramics, detergents, and enamels, contributing to their properties and performance.
Used in Dyeing:
Sodium Phosphate, Dibasic is used as a mordant in dyeing, helping to fix dyes onto fabrics and improve colorfastness.
Used in Fireproofing:
Sodium Phosphate, Dibasic is used for fireproofing paper and wood, enhancing their resistance to fire and reducing the risk of combustion.
Used in Textile Industry:
Sodium Phosphate, Dibasic is used for weighting and printing silk, improving the quality and appearance of the fabric.
Used in Water Treatment:
Sodium Phosphate, Dibasic is used in the treatment of boiler water, preventing scale formation and improving the efficiency of the system.
Used in Food Industry:
Sodium Phosphate, Dibasic is used as a sequestrant in the food industry, helping to improve the texture, stability, and shelf life of various products.
Used as a Dietary Supplement:
Sodium Phosphate, Dibasic can be used as a dietary supplement and as a nutrient, providing essential sodium for nerve and muscle functioning.
Used in Pharmaceutical Applications:
Sodium Phosphate, Dibasic is used therapeutically as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.
Used in Water Treatment and Detergents:
Sodium Phosphate, Dibasic is used in conjunction with trisodium phosphate in foods and water treatment to adjust pH and retard calcium scale formation. It is also found in some detergents and cleaning agents.
Used in Biological Assays:
Sodium Phosphate, Dibasic is used in conjunction with Sodium Phosphate, Monobasic in the preparation of biological assay buffers, which are essential for various biological and medical research applications.
Used in Purification of Antibodies:
Sodium Phosphate, Dibasic is known to be used in the purification of antibodies, a crucial process in the development of pharmaceuticals and medical treatments.
Physical and Chemical Properties:
The anhydrous compound of Sodium Phosphate, Dibasic is a white crystalline powder with a density of 1.70 g/cm3. It is hygroscopic and soluble in water but insoluble in alcohol. It converts to sodium pyrophosphate at 240°C. The dihydrate, heptahydrate, and dodecahydrate forms are also available, each with different physical properties and water content. All hydrates are soluble in water and insoluble in alcohol. Sodium hydrogen phosphate, NaH2PO4·H2O, is a hygroscopic, transparent, water-soluble crystal used as a purgative, reagent, and buffer. Disodium phosphate is available in an anhydrous form or containing two molecules of water of hydration.

Preparation

Dibasic sodium phosphate is prepared by treating phosphoric acid with a slight excess of sodium carbonate. The solution is boiled to expel carbon dioxide. Upon cooling dodecahydrate crystallizes out. Heating dodecahydrate at 100°C forms the anhydrous salt. H3PO4 + Na2CO3 → Na2HPO4 + CO2 + H2O Dibasic sodium phosphate also is prepared by reacting dibasic calcium phosphate with sodium carbonate. The product calcium carbonate precipitates leaving dibasic sodium salt in the solution. The solution on cooling yields crystals of hydrated product. CaHPO4 + Na2CO3 → CaCO3 + Na2HPO4

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Sodium phosphate dibasic is an important component of running buffer of denaturing gel electrophoresis. It induces glomerular calcification as well as other nephrotic syndrome in Sprague-Dawley rats.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. A skin and eye irritant. When heated to decomposition it emits toxic fumes of POx and Na2O. See also PHOSPHATES.

Purification Methods

Crystallise the salt twice from warm water, by cooling. Dry in air, then in an oven overnight at 130o. It should be dried before use as it is slightly hygroscopic. It forms di-, hepta-and deca-hydrates.

InChI:InChI=1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2