7561-62-8Relevant academic research and scientific papers
Sterically Hindered Free Radicals. Part 22. Dimerization and EPR Spectroscopy of Indanedionyl and 9-Acylfluorenyl Radicals
Harnack, Christian,Krull, Wolfgang,Lehnig, Manfred,Neumann, Wilhelm P.,Zarkadis, Antonios K.
, p. 1247 - 1252 (2007/10/02)
2-Phenylindanedionyl radicals 5a, their p- and o-monosubstituted derivatives and related compounds 5b-h recombine by C-C bond formation giving 6a-h.In contrast, o-substituted derivatives 5i-k and the 2-tert-butylindanedionyl radicals 5l react to give the
Hypolipidemic Activity of Indan-1,3-dione Derivatives in Rodents
Murthy, A. R.,Wyrick, S. D.,Hall, I. H.
, p. 1591 - 1596 (2007/10/02)
A series of 2-substituted indan-1,3-dione derivatives, including alkyl (C-1-C-5), mono- and disubstituted phenyl, and other 2-aryl derivatives, were tested for hypolipidemic activity of CF1 male mice at 20 mg/kg per day.These derivatives reduced both serum cholesterol and triglycerides after 16 days of administration intraperitoneally. 2-(4-Methoxyphenyl)indan-1,3-dione was one of the more active compounds with 41percent reduction of serum cholesterol and 58percent reduction of serum triglyceride levels on day 16.This activity was confirmed in the rat after oral administration. 2-(2-Methylphenyl)- and 2-(4-chlorophenyl)indan-1,3-dione were effective in reducing serum triglyceride levels 58percent and 53percent, respectively, in mice.Serum cholesterol on day 16 was effectively reduced 46percent by 2-(2,4-dimethylphenyl)indan-1,3-dione.The indan-1,3-dione derivatives were more effective than clofibrate in lowering lipid levels in mice.A more detailed study on the effects of 2-(4-methoxyphenyl)indan-1,3-dione demonstrated that key enzymes in the de novo synthesis of lipids were inhibited by the drug lowering tissue levels of lipids but raising those in the feces.The alterations in lipid content of rat lipoprotein fractions by the drug appeared favorable.
