75612-74-7Relevant academic research and scientific papers
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Babkov, Denis A.,Khandazhinskaya, Anastasia L.,Chizhov, Alexander O.,Andrei, Graciela,Snoeck, Robert,Seley-Radtke, Katherine L.,Novikov, Mikhail S.
, p. 7035 - 7044 (2015/11/11)
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
Synthesis and liquid-crystalline properties of bromoalkyloxy-substituted terphenylenes
Larios-Lopez, Leticiu,Navarro-Rodriguez, Damaso,Donnio, Bertrand,Guillon, Daniel
, p. 652 - 653 (2007/10/03)
A series of bromoalkyloxy-substituted terphenylenes were synthesized through a Palladium cross-coupling reaction between arylboronic acids and bromoaryl derivatives. By DSC it was observed that these intermediates show a rich thermotropism in a wide range of temperature (110-180°C) and by X-ray diffraction it was determined that the liquid-crystalline nature corresponds to tilted type smectic mesophases (SmC, SmF/SmI, and a two-dimensional ordered tilted mesophase SmX). Copyright
