75613-95-5

Upstream product

• 91-22-5 quinoline 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 1186305-77-0 dimethyl 3-(4-bromobenzoyl)pyrrolo[1,2-a]quinoline-1,2-dicarboxylate 
• 374679-45-5 ethyl 1-(4-bromobenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616392-05-2 ethyl 2-(4-bromophenyl)pyrrolo[1,2-a]quinoline-3-carboxylate 
• 5195-29-9 4-bromophenylglyoxal 

Relevant academic research and scientific papers

Synthesis and biological screening of new cyano-substituted pyrrole fused (Iso)quinoline derivatives

Several new cyano-substituted derivatives with pyrrolo[1,2-a]quinoline and pyrrolo[2,1a]isoquinoline scaffolds were synthesized by the [3 + 2] cycloaddition of (iso)quinolinium ylides to fumaronitrile. The cycloimmonium ylides reacted in situ as 1,3-dipol

Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents

A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c

Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents

A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c

Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events

Abstract A new family of 3-aroylindolizines bearing a dimethoxytriazine unit in their position 1 was designed, synthesized and evaluated for their ability to inhibit tubulin polymerization and cellular growth in vitro. Compound 39 was the best candidate i

Synthesis of benzoindolizine derivatives by reaction of trimethyl phosphite, dialkyl acetylenedicarboxylates and isoquinolinium or quinolinium bromides

The reactive 1:1 adduct produced by the addition of trimethyl phosphite to dialkyl acetylenedicarboxylates protonated by isoquinolinium or quinolinium bromides to afford isoquinolinium or quinolinium ylides and vinyl phosphonium bromides. 1,3-Dipolar cycl

A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process

A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their

Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives

New derivatives of quinoline (CAS 91-22-5, Z-1) were synthesized and their potential therapeutical significance and structure-activity relationship were tested. The brine shrimp bioassay was carried out to study their in vitro cytotoxicity, and besides, a