75615-28-0Relevant academic research and scientific papers
1-Aroyl-5-nitrobenzotriazole. 6. Antiinflammatory agents
Kreutzberger,Stratmann
, p. 1250 - 1252 (2007/10/02)
Based on the concept of the anellated heterocycle as the common structural characteristic of a series of antiinflammatory agents, 5-nitrobenzotriazole (1) was caused to react with cinnamoyl chloride (2a) and 4-fluorobenzoyl chloride (2b). The structure of the end products 1-cinnamoyl-5-nitrobenzotriazole (3a) and 1-(4-fluorobenzoyl)-5-nitrobenzotriazole (3b) is supported spectroscopically. 3a exhibits marked antiinflammatory activity.
