75621-50-0Relevant academic research and scientific papers
Synthesis and Antimicrobial Activities of Novel Quinazolinone Acylhydrazone Derivatives Containing the Indole Moiety
Li, Xiao-Qin,Gan, Yi-Yuan,Meng, Jiao,Li, Wen,Chen, Jie,Qi, Ya-Yun,Tian, Kun,Ouyang, Gui-Ping,Wang, Zhen-Chao
, p. 1382 - 1390 (2018/04/25)
A series of novel quinazolinone acylhydrazone derivatives containing the indole moiety were designed, synthesized, and evaluated for their inhibition activities against some important phytopathogens in vitro. Antibacterial experiments indicated that some compounds exhibited remarkable inhibition activities against tested bacteria. Especially, the EC50 values of 7a (EC50?=?55.13?μg/mL against Xoo, EC50?=?56.92?μg/mL against Rs) demonstrated the best antibacterial activities against Xoo and Rs than the other compounds, and the control agents Bismerthiazol (EC50?=?89.80?μg/mL against Xoo) and Thiodiazole copper (EC50?=?189.52?μg/mL against Rs), moreover, compound 7o (EC50?=?50.80?μg/mL) displayed the excellent activity against Xac than the control Bismerthiazol (EC50?=?56.92?μg/mL).
SINTESI ED ATTIVITA ANTIBATTERICA IN VITRO DI N-METILNITRONI E NITROVINILI DERIVATI DA ALCUNE 2-CLOROINDOL-3-CARBOSSIALDEIDI N-SOSTITUITE
Gatti, R.,Cavrini, V.,Roveri, P.,Bianucci, F.,Legnani, P.
, p. 102 - 108 (2007/10/02)
N-methylnitrones and nitrovinyl derivatives from 1-substituted-2-chloroindole-3-carboxaldehydes were synthesized and evaluated for their in vitro antibacterial activity.Some nitrovinyl derivatives displayed good in vitro activity against Gram-positive bacteria; the compound (II e), 1-(o-chlorobenzyl)-2-chloro-3-(2-nitroethenyl)indole, was more active than nitrofurantoin against Staphylococcus aureus and Streptococcus pyogenes.Some structure-activity relationships are discussed.
