75630-57-8Relevant academic research and scientific papers
Mn(III)-mediated chlorination of conjugated ketones
Liu, Xingchao,Wang, Lu,Zou, Jianping
experimental part, p. 2097 - 2100 (2012/03/11)
Mn(III)-Cl formed by the reaction of Mn(OAc)3 and hydrochloric acid in situ, reacted with α,β-unsaturated ketones readily to afford α,β-dichloroketones in good yields under mild conditions. The products are key precursors for synthesis of conjugated alkyn
Pyrolitic Elimination of Hydrogen Halide and Halogen from 2,3-Dihalogenoketones
Donnely, John A.,Quigley, Killian
, p. 1299 - 1305 (2007/10/02)
The thermal elimination of hydrogen chloride from 2'-hydroxychalcone dichlorides occured in two stages, initially forming 3-chloroflavones and then flavones; α-chloro-2'-hydroxychalcones, the likely intermediates in the formation of 3-chloroflavones, also yielded the same products.The pyrolysis of 2'-hydroxychalcone dibromides resulted in debromination as well as dehydrobromination with the consequent appearence of brominated flavones among the products.The formation of 3-bromoflavones was not observed but the isomeric (E)-α-bromo-2'-hydroxychalcones thermally isomerized to their (Z)-isomers and then underwent cyclization and dehydrobromination.The bromide were considerably more reactive than the dichlorides but, as a synthetic procedure, the pyrolysis of the dichlorides is cleaner and more productive.
