75643-45-7Relevant academic research and scientific papers
CCSO nano catalyzed solid phase synthesis of 3-oxo-5,6-disubstituted-2,3-dihydropyridazine-4-carbonitrile
Singh, Praveen,Kumar, Ranjeet,Yadav, Brijesh Kumar,Khanna, Ranjana S.,Tewari, Ashish Kumar
, p. 51239 - 51243 (2014/12/11)
Co-doped Ce0.94Ca0.05Sr0.01O1.94 (CCSO) nano particles have been successfully synthesized by an auto-combustion method and were characterized by XRD, TEM and AFM analyses. The catalytic activity of the nano-catalyst is evaluated by the synthesis of substituted pyridazines from substituted benzil and cyano acetylhydrazide, which have great biological and pharmaceutical interest. Thus, a highly economically efficient one-pot solvent free synthesis of pyridazine was developed, which is promoted by the CCSO nano catalyst. The benefits of the reaction are its very short time (2-4 min) and high yields (90-95%). The method offers a highly convergent, inexpensive, and functionality-tolerable procedure for rapid access to important pyridazine compounds in good yields. This journal is
Antihypertensive pyridazin(2H)-3-ones
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, (2008/06/13)
Compounds of the formula STR1 are useful antihypertensive agents.
Antihypertensive 5,6-diarylpyridazin-3-ones
Buchman,Scozzie,Ariyan,Heilman,Rippin,Pyne,Powers,Matthews
, p. 1398 - 1405 (2007/10/02)
The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent co
