Cas 756459-89-9,acetic acid 6,7-dimethoxy-1-[2-(1-oxo-4-pyridin-3-ylmethyl-1<i>H</i>-phthalazin-2-yl)-pyridin-4-yl]-3,4-dihydro-isoquinolin-3-ylmethyl ester

756459-89-9

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Basic information

Product Name: acetic acid 6,7-dimethoxy-1-[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridin-4-yl]-3,4-dihydro-isoquinolin-3-ylmethyl ester
Synonyms: acetic acid 6,7-dimethoxy-1-[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridin-4-yl]-3,4-dihydro-isoquinolin-3-ylmethyl ester
CAS NO:756459-89-9
Molecular Formula:
Molecular Weight: 575.624
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: acetic acid 6,7-dimethoxy-1-[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridin-4-yl]-3,4-dihydro-isoquinolin-3-ylmethyl ester(CAS DataBase Reference)
NIST Chemistry Reference: acetic acid 6,7-dimethoxy-1-[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridin-4-yl]-3,4-dihydro-isoquinolin-3-ylmethyl ester(756459-89-9)
EPA Substance Registry System: acetic acid 6,7-dimethoxy-1-[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridin-4-yl]-3,4-dihydro-isoquinolin-3-ylmethyl ester(756459-89-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 756459-89-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 756459-89-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,4,5 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 756459-89:
(8*7)+(7*5)+(6*6)+(5*4)+(4*5)+(3*9)+(2*8)+(1*9)=219
219 % 10 = 9
So 756459-89-9 is a valid CAS Registry Number.

756459-89-9Upstream product

66572-56-3 2-bromoisonicotinic acid

756459-89-9Downstream Products

756459-89-9Relevant academic research and scientific papers

Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors

Ukita, Tatsuzo,Sugahara, Masakatsu,Terakawa, Yoshihiro,Kuroda, Tooru,Wada, Kazuteru,Nakata, Aya,Kikkawa, Hideo,Ikezawa, Katsuo,Naito, Kazuaki

, p. 2347 - 2350 (2007/10/03)

A novel series of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives has been prepared. These compounds showed potent PDE4 inhibitory activities and a broad margin between the Ki value of the rolipram binding affinity and the IC50 value of PDE4 inhibition. They also exhibited potent inhibitory activities toward LPS-induced TNF-α production in mice.

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