75647-90-4

Basic information

• Product Name: Cyclopropyl methoxylamine
• Synonyms: O-CYCLOPROPYLMETHYLHYDROXYLAMINE;CYCLOPROPYL METHOXYLAMIN;CYCLOPROPYL METHOXYLAMINE;Cyclopropyl Methoxyamine;Hydroxylamine, O-(cyclopropylmethyl)-;2-(aMinooxy) Methylcyclopropane
• CAS NO: 75647-90-4
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.12
• Product Categories: Cycloalkanes
• Mol File: 75647-90-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 147.7 °C at 760 mmHg
• Flash Point: 54.5 °C
• Appearance: /
• Density: 1.032 g/cm³
• Vapor Pressure: 4.37mmHg at 25°C
• CAS DataBase Reference: Cyclopropyl methoxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropyl methoxylamine(75647-90-4)
• EPA Substance Registry System: Cyclopropyl methoxylamine(75647-90-4)

Safety Data

• Hazardous Substances Data: 75647-90-4(Hazardous Substances Data)

Usage

General Description

Cyclopropyl methoxylamine is a chemical compound with the molecular formula C4H9NO. It falls under the category of organic compounds known as amines, which are characterized by the presence of a functional group composed of a nitrogen atom connected to hydrogen atoms, alkyl groups, or aryl groups. The unique chemical structure of cyclopropyl methoxylamine, which features a cyclopropyl group (a three-carbon ring) and a methoxy group attached to the nitrogen atom, gives it different properties and potential applications in various fields like the pharmaceutical industry. It should be handled with care due to its reactivity and potential health hazards.

InChI:InChI=1/C4H9NO.ClH/c5-6-3-4-1-2-4;/h4H,1-3,5H2;1H

Upstream product

• 113211-15-7 2-(cyclopropylmethoxy)isoindoline-1,3-dione 
• 2516-33-8 Cyclopropylmethanol 

Downstream Products

• 212631-61-3 N-cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methyl-phenylamino)-benzamide 
• 880472-88-8 C₁₄H₁₆ClF₃N₂O₃S 
• 880472-79-7 N-[4-chloro-2-(1-cyclopropylmethoxyiminoethyl)phenyl]trifluoromethanesulfonamide 
• 1393352-42-5 (E)-1-{3-[3-(1-methyl-1H-pyrazol-4-yl)quinolin-6-ylmethyl][1,2,4]triazolo[4,3-b]pyridazin-6-yl}ethanone O-cyclopropylmethyloxime 

Relevant articles and documents

O-Isocyanates as Uncharged 1,3-Dipole Equivalents in [3+2] Cycloadditions

1,3-Dipoles are commonly used in [3+2] cycloadditions, whereas isoelectronic uncharged dipole variants remain underdeveloped. In contrast to conventional 1,3-dipoles, uncharged dipole equivalents form zwitterionic cycloadducts, which can be exploited to build further molecular complexity. In this work, the first cycloadditions of oxygen-substituted isocyanates (O-isocyanates) were studied experimentally and by DFT calculations. This unique cycloaddition strategy provides access to a novel class of heterocycle aza-oxonium ylides through intramolecular and intermolecular cycloadditions with alkenes. This allowed a systematic study of the reactivity of the transient aza-oxonium ylide intermediate, which can undergo N?O bond cleavage followed by nitrene C?H insertion, and the formation of β-lactams or isoxazolidinones upon varying the structure of the alkene or O-isocyanate reagents.

HETEROCYCLIC OXIME COMPOUNDS

The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

Design, synthesis, bioactivity, and structure-activity relationship (SAR) studies of novel benzoylphenylureas containing oxime ether group

Novel benzoylphenylureas containing an oxime ether group were designed and synthesized by four schemes. These benzoylphenylureas were identified by 1H NMR spectroscopy and element analysis (or HRMS). The bioactivities of the new compounds were evaluated. These benzoylphenylureas exhibited excellent larvicidal activities against oriental armyworm, some of which were much better in comparison with the commercial Flucycloxuron. In particular, the larvicidal activities against oriental armyworm of compounds 1 and 23 were 5-10 times better than that of Flucycloxuron. Most of these benzoylphenyureas exhibited excellent larvicidal activities against mosquito. At the same time, some of these compounds have good plant growth regulatory activities as well.