756499-59-9

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 756499-56-6 3-methyl-7-phenyl-3,5-dihydrofuro[3,2-c]pyridine-2,4-dione 
• 756499-69-1 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-yl)propionic acid 
• 756499-58-8 ethyl 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-yl)propionate 
• 756499-57-7 ethyl 3-(4-chlorophenylsulfanyl)-2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-yl)propionate 

Downstream Products

• 756499-61-3 4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one 
• 756499-67-9 2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)propyl trifluoroacetate 
• 756499-63-5 4-hydroxy-3-(2-hydroxy-1-methylethyl)-5-phenyl-1H-pyridin-2-one 
• 756499-56-6 3-methyl-7-phenyl-3,5-dihydrofuro[3,2-c]pyridine-2,4-dione 

Relevant academic research and scientific papers

Synthesis of cladobotryal, CJ16,169, and CJ16,170

(Equation Presented) Condensation of hydroxypyridone 7 with ethyl pyruvate and p-chlorothiophenol, reduction, and cyclization afforded 77% of lactone 6. Protection of the pyridone, acylation of the enolate with tigloyl chloride, and deprotection provided keto lactone 22. Reduction and dehydrative cyclization completed short and efficient syntheses of 2 and 3.