75652-77-6Relevant academic research and scientific papers
Structural Investigations of 3-Acylpyrrolidine-2,4-diones by Nuclear Magnetic Resonance Spectroscopy and X-Ray Crystallography
Nolte, Magriet J.,Steyn, Pieter S.,Wessels, Philippus L.
, p. 1057 - 1065 (2007/10/02)
The 3-acylpyrrolidine-2,4-diones (tetramic acids) can exist in solution as pairs of internal tautomers and as a pair of external tautomers.The tautomer constitution of a number of bioactive 3-acylpyrrolidine-2,4-diones, e.g. α-cyclopiazonic acid (1) and tenuazonic acid (3), has been studied.The study was facilitated by 1H and 13C n.m.r. spectroscopy and single crystal X-ray crystallography.From these results the structures of a number of natural products containing the 3-acylpyrrolidine-2,4-dione unit have been revised.
