756525-93-6 Usage
Description
alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol), also known as Mal-amido-PEG8-NHS, is a heterobifunctional crosslinker containing a PEG linker with a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media, while the NHS ester can be used to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group reacts with a thiol group to form a covalent bond, enabling the connection of biomolecules with a thiol.
Uses
Used in Bioconjugation:
alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) is used as a heterobifunctional crosslinker for linking amineto sulfhydryl-containing compounds or biomolecules. The maleimide functional group reacts with sulfhydryls, and the succinimidyl ester group reacts with amines, allowing for the formation of stable covalent bonds between molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG spacer and reactive groups facilitate the attachment of drugs to targeting moieties or other functional groups, enhancing the overall performance of the drug delivery system.
Used in Diagnostics and Imaging:
In the medical diagnostics and imaging fields, alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) is used as a labeling agent for the conjugation of imaging agents or contrast agents to biomolecules, such as antibodies or peptides. This allows for the specific targeting and visualization of diseased tissues or cells, improving the accuracy and effectiveness of diagnostic procedures.
Used in Research and Development:
In the research and development of new biomaterials, alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) is used as a versatile building block for the synthesis of novel bioconjugates, such as peptide-drug conjugates, protein-drug conjugates, and other hybrid systems. The unique combination of reactive groups and hydrophilic spacer allows researchers to explore new avenues in the design and development of advanced biomaterials for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 756525-93-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,5,2 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 756525-93:
(8*7)+(7*5)+(6*6)+(5*5)+(4*2)+(3*5)+(2*9)+(1*3)=196
196 % 10 = 6
So 756525-93-6 is a valid CAS Registry Number.
