756526-03-1 Usage
Description
Bis(NHS)PEG5, also known as Bis-PEG5-NHS ester, is a PEG linker containing two N-hydroxysuccinimide (NHS) ester groups. It is a homogeneous compound with a defined molecular weight and spacer arm length, which provides greater precision in optimization and characterization of crosslinking applications. The hydrophilic PEG spacer increases solubility in aqueous media, and the NHS ester can be used to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Uses
Used in Pharmaceutical Industry:
Bis(NHS)PEG5 is used as a crosslinking agent for protein structure and protein interaction analysis. It helps in low-resolution 3-D studies of protein structures, providing valuable insights into their functions and interactions.
Used in Drug Delivery Systems:
Bis(NHS)PEG5 is used as a PEGylation agent to improve the solubility, stability, and bioavailability of drugs. By attaching Bis(NHS)PEG5 to drug molecules, it enhances their circulation time in the body and reduces immunogenicity, leading to better therapeutic outcomes.
Used in Cancer Research:
Bis(NHS)PEG5 is used as a targeting agent for M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide conjugates with anti-cancer drugs. This application helps in the development of more effective cancer therapies by specifically targeting tumor-associated macrophages, which play a crucial role in tumor progression and immune evasion.
Check Digit Verification of cas no
The CAS Registry Mumber 756526-03-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,5,2 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 756526-03:
(8*7)+(7*5)+(6*6)+(5*5)+(4*2)+(3*6)+(2*0)+(1*3)=181
181 % 10 = 1
So 756526-03-1 is a valid CAS Registry Number.
