75657-73-7Relevant academic research and scientific papers
A new synthesis of peptidyl epoxysuccinates for probing cysteine protease-inhibitor P3/S3 binding interactions
Roush, William R.,Hernandez, Alejandro Alvarez,Zepeda, Gerardo
, p. 1500 - 1504 (2007/10/03)
A new synthesis of peptidyl epoxysuccinates has been developed involving the N-acylation of amino acid benzyl esters (12) with the tartrate ester derived epoxy acid 13 followed by deprotection of the benzyl esters and acylation with amines 21-28. This syn
EPOXYSUCCINIC ACID DERIVATIVES, THEIR PRODUCTION AND USE
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, (2008/06/13)
The present invention relates to a compound of the formula: STR1 wherein R 1 stands for an optionally esterified or amidated carboxyl group, X stands for an optionally substituted divalent hydrocarbon residue, R 2 stands for hydrogen or an optionally subs
E-64 analogs as inhibitors of cathepsin L and cathepsin S: Importance of the S2-P2 interactions for potency and selectivity
Gour-Salin,Goursalin,Lachance,Bonneau,Storer,Kirschke,Broemme
, p. 227 - 241 (2007/10/02)
A number of epoxysuccinyl amino acid benzyl esters (HO-Eps-AA-OBzl, 1) in which the amino acid (AA) had been systematically varied were tested as inhibitors of cathepsins L and S. These E-64 analogs were designed to investigate whether selectivity for cat
