75663-40-0

Upstream product

• 904744-96-3 7-(4-hydroxy-but-2-ynyloxy)-4-methyl-chromen-2-one 
• 4063-41-6 4,5'-dimethylangelicin 
• 107-30-2 chloromethyl methyl ether 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 904744-95-2 benzoic acid 4-(4-methyl-2-oxo-2H-chromen-7-yloxy)-but-2-ynyl ester 
• 75663-43-3 4'-chloromethyl-4,5'-dimethylangelicin 

Relevant academic research and scientific papers

New monofunctional reagents for DNA as possible agents for the photochemotherapy of psoriasis: Derivatives of 4,5'-dimethylangelicin

With the aim of obtaining new agents for the photochemotherapy of psoriasis, the authors have prepared monofunctional reagents for DNA by starting from 4,5'-dimethylangelicin (2), an angular furocoumarin, and introducing in a 4'-(hydroxymethyl)(3), 4'-(methoxymethyl)(4), or 4'-(aminomethyl) group (5), in way analogous to what other authors have done previously on trioxsalen, a DNA bifunctional reagent. These new compounds form complexes with DNA in the ground state and by successive irradiation (UV-A) undergo monofunctional photoaddition to the macromolecule. Photobinding to DNA was highest for 3 and gradually lower for 4 and 5, respectively. These compounds do not form interstrand photocross-linkages in DNA and do not show any skin phototoxicity. Fluorimetric studies show that their 4',5' double bond is involved in the photoaddition to DNA. Their photobiological activity evaluated on Ehrlich ascites tumor cells and on T2 phages was strictly connected with their photobinding to DNA. The effect of the introduction of hydroxymethyl and methoxymethyl groups in angular 2 is somewhat similar to that previously described for trioxsalen: the introduction of an aminomethyl group in 2 markedly increases the affinity in the dark for DNA but under UV-A irradiation strongly inhibits photobinding to the macromolecule. By contrast, in the analogous derivative of trioxsalen both the affinity for DNA in the dark and the photobinding to DNA increased.

Microwave-assisted Claisen rearrangement. Application to the synthesis of Angelicin derivatives

4-(Hydroxy, chloro, amino, acetoxy and methoxy)-methyl- 4,5-dimethylangelicins were efficiently and rapidly synthesized via Claisen rearrangement of 4-methyl-7-[4-(hydroxy, chloro, amino, acetoxy and methoxy)-but-2-ynyloxy]-coumarins respectively under mi

Photochemical nucleic acid-labeling reagent having a polyalkylamine spacer

A photochemical nucleic acid-labeling reagent of the formula STR1 wherein Q is a photoreactive residue of a nucleic acid-binding ligand; L is a detectable label residue; R is hydrogen, C1 to C7 -alkyl, aryl, hydroxy, or C1 to C7 -alkoxy; x is an integer from 2 through 7; and y is an integer from 3 through 10; wherein R and x, respectively, can be the same or different each time they appear in the formula. The reagent is useful in the highly efficient labeling of nucleic acids for the purpose of detection in hybridization assays.

Furocoumarin for the photochemotherapy of psoriasis and related skin diseases

A class of alkyl-substituted angular flurocoumarins, sometimes termed alkylangelicins, useful in the photochemotherapy of psoriasis and in other skin diseases characterized by cellular hyperproliferation or lack of skin pigmentation is disclosed for topical application or systemic administration. Compared with conventional psoralens the described compounds exhibit a lower risk of skin cancer, absence of phototoxicity problems anderithema to the patient so treated. One preferred compound is 5-methylangelicin.