75666-48-7

Upstream product

• 68290-18-6 4-methylthio-2-azetidinone 
• 5437-45-6 Benzyl bromoacetate 

Downstream Products

• 75666-49-8 benzyl 2-(4'-chloro-2-'oxoazetidin-1'-yl)acetate 
• 80231-87-4 benzyl 2-(4-azido-2-oxo-azetidin-1-yl)acetate 
• 80231-90-9 benzyl 7,8-dihydro-4-methyl-7-oxo-8aH-azeto<1,2-a>-v-triazolo<3,4-c>pyrimidine-5-carboxylate 
• 80231-89-6 2-(2-Azido-4-oxo-azetidin-1-yl)-3-hydroxy-3-methyl-pent-4-ynoic acid benzyl ester 
• 80231-88-5 benzyl 4,5,7,8-tetrahydro-4-hydroxy-4-methyl-7-oxo-8aH-azeto<1,2-a>-v-triazolo<3,4-c>pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Azetidinone derivatives for the treatment of atherosclerosis

PCT No. PCT/EP95/04202 Sec. 371 Date Sep. 30, 1997 Sec. 102(e) Date Sep. 30, 1997 PCT Filed Oct. 25, 1995 PCT Pub. No. WO96/13484 PCT Pub. Date May 9, 1996Azetidinone derivatives of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen or C(1-8)alkyl; R3 is C(1-8)alkyl or C(3-8)cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; and n is 0, 1 or 2; and excluding benzyl (4-methylthio-2-oxo-azetidin-1-yl)acetate are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.

Synthesis of Novel Fused &β-Lactams by Intramolecular 1,3-Dipolar Cycloadditions. Part 1. Tricyclic Triazoles

4-Azido-1-alk-2-ynylazetidin-2-ones (3), (14), and (19) when heated in refluxing toluene gave smooth intramolecular cycloaddition of the azido-group to the acetylene function to afford the corresponding 4H,7aH-azeto-v-triazoloimidazol-6(7H)-