75668-94-9Relevant academic research and scientific papers
Facile one-pot transformation of phenols into o-cyanophenols
Nakai, Yuhta,Moriyama, Katsuhiko,Togo, Hideo
, p. 6077 - 6083 (2015/03/30)
The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.
HETEROCYCLIC ACIDS
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, (2008/06/13)
The invention concerns novel 1,3-dioxane alkenoic acid derivatives of the formula I wherein: n is the integer 1 or 2; Y is methyleneoxy, vinylene or ethylene; A1 is (1-6C)alkylene; R1 is a group of the formula R2A2 --, in which: R2 is phenyl unsubstituted
