75671-08-8

Upstream product

• 75671-07-7 N-<2-(5-methoxy-3-indolyl)ethyl>-2-chloro-2-phenylacetamide 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 101-41-7 benzeneacetic acid methyl ester 
• 109933-65-5 phenyl-acetic acid-[2-(5-methoxy-indol-3-yl)-ethylamide] 

Downstream Products

• 75671-14-6 9-methoxy-3-methyl-5-phenyl-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole 
• 75671-09-9 9-methoxy-5-phenyl-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole 

Relevant academic research and scientific papers

Blue LED Mediated Intramolecular C-H Functionalization and Cyclopropanation of Tryptamines: Synthesis of Azepino[4, 5-b]indoles and Natural Product Inspired Polycyclic Indoles

We report a novel blue LED mediated intramolecular C-H functionalization of tryptamine derivatives to generate azepino[4, 5-b]indoles (4) in moderate to good yields. By altering the substitution at the tryptamine nitrogen, intramolecular cyclopropanation is achieved in high yields under the same reactions condition to provide natural product inspired polycyclic indoles (6), which are further transformed to spiropiperidino (5 and 8) indoles in decent yields. The mechanism of formation of the compounds was investigated through DFT studies.

Synthesis of Some 5-Phenylhexahydroazepinoindoles as Potential Neuroleptic Agents

5-Phenyl-1,2,3,4,5,6-hexahydroazepinoindole (3a) and five derivatives have been prepared and screened for neuroleptic activity.None of the compounds antagonized methamphetamine aggregate toxicity in mice.A number of compounds, including 3a and its