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Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate is a chemical compound characterized by the molecular formula C12H10ClNO2S. It is a thiazole derivative that features an ethyl ester functional group, a chlorine-substituted phenyl ring, and a carboxylate group. Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate is recognized for its potential applications in various fields due to its unique structural attributes and biological activities.

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  • 75680-91-0 Structure
  • Basic information

    1. Product Name: Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate
    2. Synonyms: Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate
    3. CAS NO:75680-91-0
    4. Molecular Formula: C12H10ClNO2S
    5. Molecular Weight: 268
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 75680-91-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate(75680-91-0)
    11. EPA Substance Registry System: Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate(75680-91-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 75680-91-0(Hazardous Substances Data)

75680-91-0 Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate is utilized as a key intermediate in the synthesis of a variety of pharmaceutical drugs. Its unique structure allows it to serve as a building block for the development of new molecules with potential therapeutic applications.
Used in Antimicrobial Applications:
Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate is studied for its potential as an antimicrobial agent, where it can be used to combat various types of bacterial infections. Its ability to inhibit bacterial growth makes it a candidate for further research and development in this area.
Used in Antifungal Applications:
Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate is also being investigated for its antifungal properties, which could be beneficial in treating fungal infections and controlling the growth of fungi in various settings.
Used in Anticancer Applications:
Research has been conducted on the compound's potential as an anticancer agent, where it may exhibit activity against cancer cells, providing a new avenue for cancer treatment.
Used in Agricultural Industry:
Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate has been explored for its potential as an insecticide, which could be used to control pests in agricultural settings, thereby protecting crops.
Used in Herbicidal Applications:
Additionally, Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate is under investigation for its potential as a herbicide, which could be employed to manage and control the growth of unwanted plants in agricultural fields and other areas.

Check Digit Verification of cas no

The CAS Registry Mumber 75680-91-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,6,8 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 75680-91:
(7*7)+(6*5)+(5*6)+(4*8)+(3*0)+(2*9)+(1*1)=160
160 % 10 = 0
So 75680-91-0 is a valid CAS Registry Number.

75680-91-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 4-(4-chlorophenyl)-1,3-thiazole-2-carboxylate

1.2 Other means of identification

Product number -
Other names ETHYL 4-(4-CHLOROPHENYL)THIAZOLE-2-CARBOXYLATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75680-91-0 SDS

75680-91-0Relevant articles and documents

Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry

Wu, Yao,Zhao, Shuang,Hu, Lei

, (2022/01/19)

In this study, we report for the first time the discovery of potent α-amylase inhibitors using principle of dynamic combinatorial chemistry. The best compound identified exhibited not only high inhibitory efficiency but also low cytotoxicity. The binding mode and possible mechanism are determined in the subsequent kinetic and molecular docking studies.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

-

Paragraph 00515-00517, (2019/06/11)

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

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Paragraph 0407; 0408, (2016/10/08)

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors

Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Kumagai, Hiroki,Kawai, Hideki

, p. 7036 - 7040 (2013/01/15)

A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-tetrahydro-2H- thiopyran-4-yl)-4-(2,4,5-trifluorophenyl)butanamide 1,1-dioxide (30) reduced blood glucose excursion in an oral glucose tolerance test by oral administration.

SPHINGOSINE KINASE INHIBITORS AND METHODS OF THEIR USE

-

Page/Page column 41, (2010/11/25)

The invention relates to compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease,

SUBSTITUTED HETEROARYL AND HETEROCYCLIC COMPOUNDS USEFUL IN TREATING INFLAMMATORY DISORDERS

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Page 13-14; 15, (2008/06/13)

This invention is directed to substituted heteroaryl and heterocyclic compounds as nicotinamide adenine dinucleotide oxidase hydride donor inhibitors useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.

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