756839-58-4

Upstream product

• 2835-99-6 4-amino-3-methylphenol 
• 64248-64-2 2,5-difluorobenzonitrile 
• 756839-57-3 5-Fluoro-2-(3-methyl-4-nitrophenoxy)-benzonitrile 

Downstream Products

• 756839-56-2 2-((1H-indazol-5-yl)oxy)-5-fluorobenzonitrile 
• 1105708-60-8 2-((1-acetyl-1H-indazol-5-yl)oxy)-5-fluorobenzonitrile 

Relevant academic research and scientific papers

Synthesis and p38 inhibitory activity of some novel substituted N,N′-diarylurea derivatives

We have identified a novel series of substituted N,N′-diarylurea p38α inhibitors. The inhibitory activity of the target compounds against the enzyme p38α, MAPKAPK2 in BHK cells, TNF-α release in LPS-stimulated THP-1 cells and p38α binding experiments were

PYRAZOLE UREA DERIVATIVES USED AS KINASE INHIBITORS

Compounds of Formula (I) where R1 and R2 are as defined herein, and pharmaceutically acceptable salts thereof, are useful in the treatment and prevention of various disorders mediated by kinases

KINASE INHIBITORS AND METHODS OF USE THEREOF

The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

P38 inhibitors and methods of use thereof

This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

P38 inhibitors and methods of use thereof

This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.