756845-67-7Relevant academic research and scientific papers
Dialkyl diazomalonates in transition-metal-free, thermally promoted, diastereoselective wolff β-lactam synthesis
Synofzik, Judith,Bakulina, Olga,Dar'in, Dmitry,Kantin, Grigory,Krasavin, Mikhail
supporting information, p. 1273 - 1276 (2020/08/21)
Metal-free, thermally promoted synthesis of 3-alkoxy-3-alkoxycarbonyl-2-azetidinones via the Wolff-Staudinger β-lactam synthesis using dialkyl diazomalonates is described. The reaction appears fairly general and delivers only one diastereomer.
Skeletal Diversity in Combinatorial Fashion: A New Format for the Castagnoli-Cushman Reaction
Lepikhina, Anastasia,Dar'In, Dmitry,Bakulina, Olga,Chupakhin, Evgeny,Krasavin, Mikhail
, p. 702 - 707 (2017/11/20)
A new format for the Castagnoli-Cushman reaction of structurally diverse dicarboxylic acids, amines, and aldehydes in the presence of acetic anhydride as dehydrating agent is described. The reaction is distinctly amenable to parallel format: the combinato
Synthesis and spectroscopic characterization of Ni(II) complexes involving functionalised dithiocarbamates and triphenylphosphine: Anagostic interaction in (N-cyclopropyl-N-(4-fluorobenzyl)dithiocarbamato-S,S′) (thiocyanato-N)(triphenylphosphine)nickel(II)
Sathiyaraj,Srinivasan,Thirumaran,Velmurugan
, p. 203 - 209 (2015/09/22)
Twelve new nickel(II) complexes namely [Ni(S2CNRR′)2](1-6) and [Ni(S2CNRR′)(NCS)(PPh3)](7-12) [where R = cyclopropyl (cPr); R′ = 2HO-C6H4-CH2- (1,7), 3HO-C6H4-CH2- (2,8), 4HO-C6H4-CH2- (3,9), 4CH3O-C6H4-CH2- (4,10), 4F-C6H4-CH2- (5,11), 4Cl-C6H4-CH2- (6,12)] have been prepared and characterized by elemental analysis, IR, UV-Vis and NMR (1H and 13C) spectroscopy. A single crystal X-ray structural analysis was carried out for (N-cyclopropyl-N-(4-fluorobenzyl)dithiocarbamato-S,S′)(thiocyanato-N)- (triphenylphosphine)nickel(II). The increase in wavenumber of νC-N thioureide and decrease in chemical shift values of heteroleptic complexes 7-12 compared to that of homoleptic complexes 1-6 are due to the mesomeric drift of electron density from the dithiocarbamate moiety towards the metal centre, increasing the carbon-nitrogen double bond character. The increased strength of C-N bond is due to the presence of the π-accepting triphenylphosphine. Electronic spectral studies indicated square planar geometry around the nickel(II) central atom for all the complexes. Single crystal X-ray structural analysis of 11 confirms that the coordination geometry about the Ni is distorted square planar. The C-H...F interactions lead to a polymeric structure and a rare intramolecular anagostic interaction [M…H = 2.929 ?] is observed. The molecular geometry, HOMO-LUMO in the ground state and MEP have been calculated for 11 using the Hartree-Fock (HF) method with the LANL2DZ basic set. The optimized bond lengths and bond angles agree well with the experimental results. The asymmetry in the Ni-S bonds reveal the greater trans influence of triphenylphosphine compared to that of the isothiocyanate ion.
Synthesis of C-aryl-N-cyclopropylnitrones
Vukics, Krisztina,Tarkanyi, Gabor,Dravecz, Ferenc,Fischer, Janos
, p. 3419 - 3425 (2007/10/03)
Synthesis of C-aryl-N-cyclopropylnitrones is described. Preparations were performed either by condensation of the appropriate aldehyde with N-cyclopropyl-hydroxylamine, or oxidation of N-substituted N-cyclopropylamines with sodium tungstate/hydrogen perox
