756894-41-4Relevant academic research and scientific papers
Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity
Anh Dang Thi, Tuyet,Pham The, Chinh,Ngo, Quoc Anh,Ha Vu Thi, Thu,Dung Nguyen, Tien,Tien Doan, Duy,Ba Thi, Cham,Jean,Van De Weghe,Nguyen Van, Tuyen
supporting information, p. 5216 - 5218 (2014/12/11)
In this Letter, the synthesis and the evaluation of the cytotoxicity of new hemiasterlin analogues were reported. The indole moiety was replaced respectively by benzofurane, naphthalene and 4-bromobenzene groups. Most of these derivatives possess strong c
Synthesis and biological activity of analogues of the antimicrotubule agent N,β,β-trimethyl-L-phenylalanyl-N1-[(1S,2E)-carboxy-1- isopropylbut-2-enyl]-N13-dimethyl-L-valinamide (HTI-286)
Zask, Arie,Birnberg, Gary,Cheung, Katherine,Kaplan, Joshua,Niu, Chuan,Norton, Emily,Suayan, Ronald,Yamashita, Ayako,Cole, Derek,Tang, Zhilian,Krishnamurthy, Girija,Williamson, Robert,Khafizova, Gulnaz,Musto, Sylvia,Hernandez, Richard,Annable, Tami,Yang, Xiaoran,Discafani, Carolyn,Beyer, Carl,Greenberger, Lee M.,Loganzo, Frank,Ayral-Kaloustian, Semiramis
, p. 4774 - 4786 (2007/10/03)
Hemiasterlin (1), a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286 (2), an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its potent
