75693-17-3

Basic information

• Product Name: 6-BROMO-1,2-DIHYDRO-NAPHTHALENE
• Synonyms: 6-BROMO-1,2-DIHYDRO-NAPHTHALENE
• CAS NO: 75693-17-3
• Molecular Formula: C₁₀H₉Br
• Molecular Weight: 209.08246
• Mol File: 75693-17-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 256.407°C at 760 mmHg
• Flash Point: 110.747°C
• Appearance: /
• Density: 1.435g/cm³
• Vapor Pressure: 0.025mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 6-BROMO-1,2-DIHYDRO-NAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-1,2-DIHYDRO-NAPHTHALENE(75693-17-3)
• EPA Substance Registry System: 6-BROMO-1,2-DIHYDRO-NAPHTHALENE(75693-17-3)

Safety Data

• Hazardous Substances Data: 75693-17-3(Hazardous Substances Data)

Usage

General Description

6-Bromo-1,2-dihydro-naphthalene, also known as 6-bromo-1,2-dihydronaphthalene or 6-bromoindan, is a chemical compound with the molecular formula C10H11Br. It is a brominated derivative of 1,2-dihydro-naphthalene, a hydrocarbon commonly found in fossil fuels and coal tar. 6-Bromo-1,2-dihydro-naphthalene is used as a building block in the synthesis of various organic compounds and pharmaceuticals. It is also used as a reagent in organic chemistry research and can be involved in the synthesis of other chemical compounds through various reactions. The compound has potential applications in drug discovery and the development of new therapeutic agents.

InChI:InChI=1/C10H9Br/c11-10-6-5-8-3-1-2-4-9(8)7-10/h2,4-7H,1,3H2

Upstream product

• 32281-97-3 7-bromo-3,4-dihydro-2H-naphthalen-1-one 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 75693-15-1 7-bromo-1,2,3,4-tetrahydronaphthalen-1-ol 

Downstream Products

• 1373215-27-0 (1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate 
• 794507-89-4 (+/-)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalene 
• 1373215-17-8 (1S,2S)-1-(4-fluorobenzamido)-7-(4-(oxetan-3-yl)piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methylcarbamate 
• 1373215-41-8 4-fluoro-N-((1S,2S)-2-hydroxy-7-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide hydrochloride 
• 1373215-40-7 tert-butyl 4-((7S,8S)-8-(4-fluorobenzamido)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)piperazine-1-carboxylate 
• 1373215-38-3 tert-butyl 4-((7S,8S)-8-(4-fluorobenzamido)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-3-oxopiperazine-1-carboxylate 
• 1373215-33-8 N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide 
• 1617524-93-2 C₁₆H₁₄ 
• 22531-20-0 6-ethyltetralin 
• 42775-77-9 6-Propyl-tetralin 
• 1680-51-9 6-methyl-1,2,3,4-tetrahydronaphthalene 
• 75693-20-8 7-bromo-1,2-epoxy-1,2,3,4-tetrahydronaphthalene 
• 2717-47-7 1,2-dihydro-6-methylnaphthalene 

Relevant articles and documents

Catalytic asymmetric intermolecular bromoesterification of unfunctionalized olefins

An asymmetric intermolecular bromoesterification of unfunctionalized olefins catalyzed by (DHQD)2PHAL is described. Optically active bromoesters can be obtained with up to 92% ee.

Cathepsin S Inhibitor Compounds

The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.

AROMATIC SUBSTITUENT EFFECT ON THE STEREOSELECTIVITY OF THE ACID-INDUCED RING OPENING OF 1,2-EPOXIDES DERIVED FROM 3,4-DIHYDRONAPHTHALENE. IMPORTANCE OF THE REACTIVE CONFORMATIONS FOR THE STEREOSELECTIVITY.

The stereochemistry of the acid-induced ring opening reactions (hydrolysis, methanolysis and trichloroacetolysis) of 1,2-epoxides derived from ring substituted 3,4-dihydronaphthalene has been examined.In every case, a satisfactory Hammett-type linear correlation was found between the diastereoselectivity of the reaction and the ?+ constant of the aromatic substituent.The stereoselectivity of the opening reaction turned out to be largely driven by the reactive conformation of the epoxide and/or of the opening process intermediates.