75693-19-5Relevant academic research and scientific papers
AuCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis
Wang, Rui,Chen, Yi,Shu, Mao,Zhao, Wenwen,Tao, Maoling,Du, Chao,Fu, Xiaoya,Li, Ao,Lin, Zhihua
supporting information, p. 1941 - 1946 (2020/02/11)
Compared with the ripeness of olefin metathesis, exploration of the construction of carbon–carbon double bonds through the catalytic carbonyl–olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl3-catalyzed intramolecular ring-closing carbonyl–olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes, polycycles, benzocarbocycles, and N-heterocycle derivatives in good to excellent yields.
Structure-based design, synthesis and antidepressant-like activity of phenylthiazolyl-1H,2H,3H,4H-naphthalene derivatives
Uppal, Archana,Singh, Anita,Kothiyal, Preeti
, p. 379 - 384 (2015/01/30)
In recent years, a bacterial homologue of SERT (LeuT) target protein was solved in complex with sertraline and offers promising pathway for the hit identification. Herein, we cover advanced computational methodology for hybrid class 1,2,3,4-tetrahydronaphalene and phenylthiazole derivatives using three two modules. First, these drug-like candidates were filtered by molecular properties from a training set of library. Second, compounds were prioritized according to previously optimized CDocker docking methodology. Finally, synthesized in silico actives were demonstrated enhanced antidepressant-like activity with reasonable non-toxicity using standard mice model (s).
Catalytic asymmetric intermolecular bromoesterification of unfunctionalized olefins
Li, Lijun,Su, Cunxiang,Liu, Xiaoqin,Tian, Hua,Shi, Yian
, p. 3728 - 3731 (2014/08/05)
An asymmetric intermolecular bromoesterification of unfunctionalized olefins catalyzed by (DHQD)2PHAL is described. Optically active bromoesters can be obtained with up to 92% ee.
Asymmetric Michael Additions. Regio-, Diastereo-, and Enantioselective Alkylations of the Enamines from β-Tetralones and (S)-2-(Methoxymethyl)pyrrolidine ("Prolinol Methyl Ether") by ω-Nitrostyrenes
Blarer, Stefan J.,Seebach, Dieter
, p. 3086 - 3096 (2007/10/02)
β-Tetralones with various substituents (CH3, NO2, OCH3, OCH2O, Cl) in 1-, 5-, 6-, 7-, and 8-position are added to ω-nitrostyrenes (2) through enamines (1) derived from (S)-2-(methoxymethyl)pyrrolidine.Hydrolysis of the primary adducts (3) yields (35 - 55percent) β-tetralones 4 alkylated in the 3-position.These are all > 90percent diastereomerically and 75 - 99percent optically pure (see u-4 and Table 1).From results of earlier investigations it is inferred, that the present reaction occurs with relative topicity lk, ul-1,4 (see 6), i.e. that the products 4 have (3S,1'R)-configuration.This is compatible with the 1H NMR and CD spectra of the isolated products of type 4.
