75698-08-7Relevant academic research and scientific papers
ISOXAZOLE CARBOXAMIDE COMPOUNDS
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Paragraph 0317, (2016/06/01)
The present disclosure provides substituted isoxazole carboxamide compounds having Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, A, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
SYNTHESIS OF 1-HYDROXY-2-(N-SUBSTITUTED)AZATWISTANES
Kadzyauskas, P. P.,Malinauskene, Yu. A.,Butkus, E. P.,Zefirov, N. S.
, p. 727 - 729 (2007/10/02)
The reductive amination of bicyclononane-2,6-dione with benzylamine or isopropylamine in the presence of sodium borohydride proceeds with the formation of 1-hydroxy-2-(N-substituted)azatwistanes.When 1-hydroxy-2-benzyl-2-azatwistane is refluxed with acetic anhydride, the ring is opened to give 2-acetoxy-6-acetylbenzylaminobicyclononane.The structures of the synthesized compounds were proved by means of the IR and PMR spectra and the results of elementary analysis.
