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Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-1-Cyclohexyl-2,2,2-trifluoroethylamine is used as a building block for the synthesis of pharmaceuticals and other organic compounds. The presence of the trifluoromethyl group in its structure imparts special characteristics that are valuable in drug discovery and development.
Used in Drug Design:
(R)-1-Cyclohexyl-2,2,2-trifluoroethylamine is used as a key component in drug design, contributing to the development of novel therapeutic agents. Its chiral nature allows for the creation of specific stereoisomers, which can have different biological activities and properties, making it an important tool in the design of new drugs.
Used in Organic Chemistry:
(R)-1-Cyclohexyl-2,2,2-trifluoroethylamine is also utilized in the broader field of organic chemistry, where it can be employed in various chemical reactions and processes to create a range of different compounds with diverse applications.

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 1427350-22-8 C₁₅H₂₀F₃N 
• 130517-97-4 N-(cyclohexylmethylidene)benzylamine 

Relevant academic research and scientific papers

Radical Transformation of Aliphatic C-H Bonds to Oxime Ethers via Hydrogen Atom Transfer

Herein, we describe a strategy for conversion of aliphatic C-H bonds to oxime ethers via hydrogen atom transfer. In this strategy, the decatungstate anion and sulfate radical play complementary roles in the abstraction of hydrogen atoms from primary, secondary, and tertiary C-H bonds of alkanes. The easy accessibility of alkanes and the broad substrate scope, mild conditions, and excellent regioselectivity of these reactions make this strategy applicable for the transformation of raw materials to high-value chemicals.

An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent

A small library of structurally diverse primary amines bearing a geminal CF3 group was synthesized on a preparative scale. The synthesis starts with an aldehyde or ketone that reacts with benzylamine yielding the corresponding imine. The latter is then trifluoromethylated with Me 3SiCF3 under acidic conditions to give a benzylalkylamine. In the last step the Pd-mediated hydrogenation of the benzylalkylamines furnishes the title compounds. All synthetic steps are high-yielding; neither the isolation of the intermediates nor the chromatographic purification of the products is necessary.

2-[Trifluoroethylamine]oxazolines

This invention relates to trifluorethylamines and to a process for producing the same. These trifluorethylamines are substituted on the nitrogen atom with a lower alkyl or a cyclo lower alkyl radical. They are endowed with interesting pharmacologi