75704-24-4 Usage
Uses
Used in Pharmaceutical Industry:
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE is used as a research chemical for the development of new antidepressant medications. Its agonist activity on the 5-hydroxytryptamine 2C receptor suggests potential therapeutic applications in treating depression and related mood disorders.
Used in Neuroscience Research:
In the field of neuroscience, 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE is used as a research tool to study the role of the 5-hydroxytryptamine 2C receptor in various neurological and psychiatric conditions. This helps researchers better understand the underlying mechanisms and develop targeted treatments.
Used in Addiction Treatment:
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE is used as a potential therapeutic agent in the treatment of nicotine addiction. Its ability to block and decrease nicotine-induced locomotor activity in rats suggests that it may help reduce cravings and withdrawal symptoms associated with nicotine dependence.
Biological Activity
Potent and selective 5-HT 2C receptor agonist (K i = 4 nM; EC 50 = 12 nM). Antidepressant following systemic administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 75704-24-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,7,0 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75704-24:
(7*7)+(6*5)+(5*7)+(4*0)+(3*4)+(2*2)+(1*4)=134
134 % 10 = 4
So 75704-24-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H11Cl2N3O.ClH/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8;/h3-4,10,14H,1-2,5H2,(H,15,17);1H
75704-24-4Relevant academic research and scientific papers
2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives
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, (2008/06/13)
This invention provides compounds of formula I, wherein R is hydrogen or alkyl of 1-6 carbon atoms; R′ is hydrogen, alkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R1, R2, R3, and R4are each, inde
2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives
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, (2008/06/13)
This invention provides compounds of formula I, wherein R is hydrogen or alkyl of 1-6 carbon atoms; R′ is hydrogen, alkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R1, R2, R3, and R4 are each, ind
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinozalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino [1,2-,a] quinoxalines
Welmaker, Gregory S.,Nelson, James A.,Sabalski, Joan E.,Sabb, Annmarie L.,Potoski, John R.,Graziano, Denise,Kagan, Michael,Coupet, Joseph,Dunlop, John,Mazandarani, Hossein,Rosenzweig-Lipson, Sharon,Sukoff, Stacey,Zhang, Yingxin
, p. 1991 - 1994 (2007/10/03)
A series of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro- 1H-pyrazino[1,2-a]-quinoxalines was shown to exhibit 5-HT(2C) agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fasted, male Sprague-Dawley rats with ED50 values of 2 mg/kg (ip) and 10 mg/kg (po). (C) 2000 Elsevier Science Ltd.
