757190-48-0

Upstream product

• 125617-18-7 3-(4-trifluoromethylphenyl)-2-propen-1-ol 

Downstream Products

• 757190-35-5 (2S,3S)-3-(4-(trifluoromethyl)phenyl)-2-(benzyloxymethyl)oxirane 
• 757190-34-4 (2S,3S)-2-(2-Nitro-benzyloxymethyl)-3-(4-trifluoromethyl-phenyl)-oxirane 
• 944804-99-3 (2R,3R)-3-azido-3-(4-(trifluoromethyl)phenyl)propane-1,2-diol. 

Relevant academic research and scientific papers

FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE

The invention relates to thiazole compounds of Formula (I) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

THIADIAZOLE MODULATORS OF PKB

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the th

Boron trifluoride-induced reactions of phenylglycidyl ethers: A convenient synthesis of enantiopure, stereodefined fluorohydrins

Ring-opening hydrofluorination of enantiomerically pure (2S,3S)-3-arylglycidyl ethers (aryl=phenyl, 4-trifluoromethylphenyl) by boron trifluoride-diethyl ether under mild conditions provides β-fluoro alcohols in good yield in a stereospecific manner with

Alkanophenones useful for treating allergies

Substituted alkanophenones of general formula STR1 in which R1 is unsubstituted or fluorinated lower alkyl, R2 is hydrogen, or unsubstituted or fluorinated lower alkyl or lower alkenyl, X is lower alkylene, oxy, thio or a direct bond, alk is lower alkylene, n is 1 or 2, R3 is phenyl that is unsubstituted or is substituted by unsubstituted or fluorinated lower alkyl, by etherified or esterified hydroxy, by unsubstituted or lower alkylated amino and/or by free, esterified or amidated carboxy, or is lower alkyl that is unsubstituted, substituted by fluoro and chloro or substituted by free esterified or amidated carboxy, R4 is free, esterified or amidated carboxy or 5-tetrazolyl, and R5 is hydrogen or lower alkyl, have leucotriene-antagonistic properties and can be used as anti-allergic active ingredients in medicaments.