757191-67-6

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 96013-55-7 1-[(4-methylphenyl)sulfonyl]-5,6-dihydro-1H-piperidin-2-one 
• 23438-61-1 1-(toluene-4-sulfonyl)piperidin-2-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 675-20-7 piperidin-2-one 

Downstream Products

• 757191-70-1 4-isopropyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate 
• 757191-75-6 1-[4-isopropyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]cyclobutanol 

Relevant academic research and scientific papers

Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium-Ring Lactams

A mild and efficient intermolecular ring-expansion approach was developed for the synthesis of medium-ring lactams by using siloxy alkynes. Key to success is the suitable combination of a superior catalyst and an exceptional nitrogen-protecting group. Control experiments indicated that the reaction is remarkably selective toward the desired lactam formation, even with many possible non-productive pathways. Growth rings: A mild catalytic synthesis of medium-ring lactams through ring expansion of cyclic hemiaminals was developed. This synthetically useful method also gives insight into the reactivity of both siloxy alkynes and N-acyliminium analogues.

Synthesis of functionalized 1-azaspirocyclic cyclopentanones using bronsted acid or N-bromosuccinimide promoted ring expansions

Azaspirocyclic ring systems are present in a variety of alkaloids. Functionalized 1-azaspirocyclopentanones (6, 7, 11, 12) can be efficiently constructed through semipinacol ring expansion reactions of 2-(1- hydroxycyclobutyl)-p-toluenesulfonylenamides (4