757236-88-7

Upstream product

• 78056-67-4 1-(phenylmethyl)-4-piperidineacetonitrile 
• 616897-44-0 2-(1-benzylpiperidin-4-ylidene)malononitrile 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 3655-05-8 tert-butoxycarbonylglycine p-nitrophenylester 
• 86945-25-7 4-(2-aminoethyl)-1-(phenylmethyl)piperidine 

Downstream Products

• 757236-89-8 2-amino-N-[2-(1-benzyl-piperidin-4-yl)-ethyl]-acetamide 

Relevant academic research and scientific papers

Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's Disease were assayed. The optimum hybrid inhibitor 3 is much more potent and selective than tacrine in vitro. Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro.