757249-30-2

Upstream product

• 353248-25-6 (+)-1-[(5S)-5-(tert-butyldimethylsilanyloxy)-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]cyclopentanol 
• 120-92-3 cyclopentanone 

Downstream Products

• 634891-90-0 (+)-(3S,6R,3'S)-3-(tert-butyldimethylsilanyloxy)-7-[3'-(4-methoxybenzyloxy)nonyl]-1-(toluene-4-sulfonyl)-1-azaspiro[5.5]undeca-4,7-diene 
• 634891-89-7 (+)-(3S,6R)-trifluoromethanesulfonic acid 3-(tert-butyldimethylsilanyloxy)-1-(toluene-4-sulfonyl)-1-azaspiro[5.5]undeca-4,7-dien-7-yl ester 
• 634891-84-2 (-)-(3S,5S,6R)-methanesulfonic acid 3-(tert-butyldimethylsilanyloxy)-7-oxo-1-(toluene-4-sulfonyl)-1-azaspiro[5.5]undec-5-yl ester 
• 353248-28-9 (-)-(3S,5S,6R)-3-(tert-butyldimethylsilanyloxy)-5-hydroxy-1-(toluene-4-sulfonyl)-1-azaspiro[5.5]undecan-7-one 
• 634891-85-3 (+)-(3S,6R)-3-(tert-butyldimethylsilanyloxy)-1-(toluene-4-sulfonyl)-1-azaspiro[5.5]undec-4-en-7-one 

Relevant academic research and scientific papers

A Formal Construction of Fasicularin

(Equation presented) Our synthetic approach toward fasicularin is presented. Key steps in this construction are a siloxy-epoxide semipinacol rearrangement, a B-alkyl Suzuki reaction and an intramolecular SN2 reaction.

An asymmetric formal synthesis of fasicularin

An asymmetric formal synthesis of fasicularin (1) is described. This natural product, isolated from the extracts of the marine invertebrate Nephteis fasicularis, has shown modest cytotoxicity towards Vero cells. Fasicularin is among only two members of th