75726-98-6

Upstream product

• 90-82-4 pseudoephedrine 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 16251-49-3 (5S,6S)-4,5-dimethyl-6-phenyl-3-morpholone 
• 1414010-48-2 (+)-(2-(((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)(methyl)amino)-2-oxoethyl)dimethylsulfonium bromide 
• 1414010-80-2 (+)-(2R,5S,6S)-2-((R)-hydroxy(phenyl)methyl)-4,5-dimethyl-6-phenylmorpholin-3-one 
• 1414010-89-1 (+)-(2R,5S,6S)-2-((R)-hydroxy(4-nitrophenyl)methyl)-4,5-dimethyl-6-phenylmorpholin-3-one 
• 1414010-92-6 (+)-(2R,5S,6S)-2-((R)-(3,4-dimethylphenyl)(hydroxy)methyl)-4,5-dimethyl-6-phenylmorpholin-3-one 
• 107365-31-1 (5S,6S)-2-Butyl-4,5-dimethyl-6-phenyl-morpholin-3-one 

Relevant academic research and scientific papers

Asymmetric syntheses of three-membered heterocycles using chiral amide-based ammonium ylides

The use of carbonyl-stabilised ammonium ylides to access chiral glycidic amides and the corresponding aziridines has so far been limited to racemic trans-selective protocols. We herein report the development of an asymmetric approach to access such compou

Diastereoselective synthesis of aryl and alkyl trans-glycidic amides from pseudoephedrine-derived sulfonium salt. Chemospecific exo-tet ring closure for morpholin-3-ones

A regiospecific and high diastereoselective synthesis of trans-glycidic amides coming from a common pseudoephedrine sulfonium salt 2 precursor is presented. This is the first example in where the diastereoselectivity is controlled by a chiral noncyclic am

ELECTROPHILIC ASYMMETRIC SYNTHESES OF α-HYDROXY CARBOXYLIC ACIDS

Asymmetric electrophilic syntheses of α-hydroxy carboxylic acids from chiral amide derivatives of tert-butyl- and trialkylsilyl- protected glycolic and lactic acids are described which lead to chiral α-hydroxy carboxylic acids in 60-95percent diastereomeric excess.