75738-81-7Relevant academic research and scientific papers
COMPOUNDS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR, INFLAMMATORY AND IMMUNE DISORDERS
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, (2008/06/13)
Enantiomerically enriched disubstituted tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i.e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.
Titanocene-Catalyzed Reduction of Lactones to Lactols
Verdaguer, Xavier,Hansen, Marcus C.,Berk, Scott C.,Buchwald, Stephen L.
, p. 8522 - 8528 (2007/10/03)
A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.
Synthesis of some 2-cyanomethyltetrahydrofuran and 2-cyanomethyltetrahydropyran derivatives
Passarotti,Valenti,Ceriani,Grianti
, p. 150 - 152 (2007/10/02)
2-cyanomethyltetrahydrofuran and 2-cyanomethyltetrahydropyran derivatives, useful in the synthesis of 3(5)-aminopyrazoles and 5-aminoisoxazoles have been prepared starting from corresponding lactones, via DIBAL-H reduction to lactols, and olefination by Wittig reaction to α, β-unsatured cyanoderivatives. These undergo instantaneous cyclization to tetrahydrofuran and tetrahydropyran derivatives.
2-SUBSTITUTED-TRANS-5-ARYL-2,3,4,4a,5,9B-HEXAHYDRO-1H-PYRIDO[4,3-b]INDOLES
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, (2008/06/13)
2-Substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido 4,3-b!indoles of the formula (I): STR1 and the pharmaceutically-acceptable salts thereof, wherein the hydrogen atoms in the 4a position and 9b positions are in a trans relationship to each other and t
