75753-37-6

Upstream product

• 74386-36-0 1-azido-4-chloro-anthraquinone 
• 2872-47-1 1-amino-4-chloroanthraquinone 

Downstream Products

• 75753-54-7 3-Piperidin-1-yl-5-p-tolylamino-anthra[1,9-cd]isoxazol-6-one 
• 39774-73-7 1-amino-4-p-tolylaminoanthraquinone 
• 80825-56-5 1-(1-Methyl-1-phenyl-ethylamino)-4-p-tolylamino-anthraquinone 

Relevant academic research and scientific papers

AMINATION OF ANTHRAISOXAZOL-6-ONES

The behavior of 3,5-dihalo derivatives of anthraisoxazol-6-one with respect to primary and secondary amines was studied. 5-Chloroanthraisoxazol-6-one undergoes amination particularly readily.The products of the reaction of isoxazoles with amines are the corresponding amino derivatives.The amination of 5-chloroanthraisoxazol-6-one in refluxing dimethylformamide (DMF) is accompanied by reductive cleavage of the isoxazole ring and the formation of 1-amino-4-arylaminoanthraquinones.Amination in the 5 position with substitution of a hydride ion takes place primarily in the reaction of 3-chloroanthraisoxazol-6-one with benzylamine or cyclohexylamine, whereas the chlorine in the 3 position is replaced by the action of morpholine or piperidine on the same substrate.