75770-58-0

Upstream product

• 1356408-91-7 imidazol-2-yl-methyl[N-(n-butyl)amino]-diphenylphosphine oxide 
• 4559-70-0 Diphenylphosphine oxide 
• 1335204-96-0 quinolin-2-yl(butylamino)methyldiphenylphosphine oxide 
• 12771-59-4 diphenylphosphinoyl radical 
• 20180-11-4 O-methyl-P,P-diphenylselenophosphinate 

Downstream Products

• 1420904-84-2 1-bromo-4-[4-bromo-2-(diphenylphosphinoyl)phenoxy]-5-(diphenylphosphinoyl)benzene 
• 1420904-81-9 1-(diphenylphosphinoyl)-2-(4-bromophenoxy)benzene 

Relevant academic research and scientific papers

The first examples of enantiomerically pure diphosphane dioxides-(R(P),R(P))- and (S(P),S(P))-1,2-di-tert-butyl-1,2-diphenyldiphosphane 1,2-dioxides, and (R(P))- and (Sp)-1-tert-butyl-1,2,2-triphenyldiphosphane 1,2-dioxides

Whereas oxidative dimerization of each of the lithiated reagents (R(P))- and (S(P))-tert-butylphenylphosphane oxides 1 Li and 2 Li by means of oxygen in THF at low temperature led cleanly to meso-1,2-di-tert-butyl-1,2-diphenyldiphosphane dioxide (3), the respective nucleophilic substitution reactions of 1 Li and 2 Li with the (R(P))- and (S(P))-tert-butylphenylphosphinic bromides (4 and 6) in THF under argon led to the corresponding (S(P),S(P))-and (R(P),R(P))-1,2-di-tert-butyl-1,2-diphenyldiphosphane dioxides (5 and 7) in good yields together with the meso-diphosphane dioxide 3. The structures of 3 and 5 were established by X-ray crystallography. Similarly, the reaction of lithiated (R(P))-phosphane oxide 1 Li with diphenylphosphinic bromide (8) or of achiral lithiated diphenylphosphane oxide 10 Li with (R(P))-tert-butylphenylphosphinic bromide (4) provided (S(P))-tert-butyltriphenyldiphosphane dioxide (9).

Preparation of new imidazol-2-yl-(amino)methylphosphonates, phosphinates and phosphine oxides and their unexpected cleavage under acidic conditions

The efficient synthesis of new imidazol-2-yl-(amino)methylphosphonic acids, phosphonates phosphinate esters and phosphine oxides is described. The synthetic methodology is based on nucleophilic addition of phosphorus species to imidazole-2 derived imines.

New quinoline-2, -3, and 4-yl-(amino) methylphosphonates: Synthesis and study on the C-P bond cleavage in quinoline-2 and -4 derivatives under acidic conditions

Synthesis of new quinoline-(amino)methylphosphonic acids, their phosphonate esters, and phosphine oxides is presented. The desired new compounds were efficiently obtained by nucleophilic addition of phosphorous species to quinoline-derived Schiff bases. In addition, it was discovered that heating of quinolin-2 and quinolin-4-yl-(amino)-methylphosphonates with aqueous HCl leads to their decomposition resulting in a rupture of the C-P bond, rejecting of the phosphorus containing fragment, and formation of the corresponding secondary quinoline-2 and quinoline-4-alkylamines. Two alternative mechanistic pathways for this cleavage are postulated. Copyright

Studies on the interaction of phosphine selenides and their structural analogues wth dihalogens and sulfuryl chloride

The phosphine selenides, tris(dimethylamino)phosphine selenide, esters of selenophosphoric acid, and esters of selenophosphonic acid react with dihalogens and sulfuryl chloride to form halogenoselenophosphonium salts (≡ 3P-SeX)+X-. T

Phosphinoyl radicals: Structure and reactivity. A laser flash photolysis and time-resolved ESR investigation

The photochemistry of a series of bis(acyl)phosphine oxides and the rate constants of the reactions of their phosphorus radicals with n-butylacrylate, thiophenol, bromotrichloromethane, oxygen, and methyl viologen have been investigated by laser flash pho

Preparation of 3-substituted cephalosporins

There is described a process for preparing an enamine of formula (IX): STR1 where R2 is a carboxylic acid protecting group and R3 is the residue of a carboxylic acid derived acyl group and where R5 and R6 are the same or different C1-4 alkyl or C7-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): STR2 with an amine of formula HNR5 R6, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3-hydroxycephalosporins.