757951-21-6Relevant articles and documents
PhIO/Et3N ? 3HF-Mediated Formation of Fluorinated 2H-Azirines via Domino Fluorination/Azirination Reaction of Enamines
Zhang, Yong,Zhao, Xiaoyuan,Zhuang, Chen,Wang, Senlin,Zhang-Negrerie, Daisy,Du, Yunfei
, p. 2107 - 2112 (2018)
A variety of enamine carboxylic esters and enaminones were converted to the biologically interesting fluorinated 2H-azirines through reactions with PhIF2 generated in situ by PhIO and Et3N ? 3HF in 1,2-dichroloethane, which features the hypervalent iodine reagents-mediated introduction of fluorine atom and formation of the 2H-azirine skeleton under metal-free conditions. The domino reaction is postulated to proceed via a PhIF2-mediated oxidative fluorination and a subsequent azirination of the fluorinated enamine intermediates. (Figure presented.).
Highly efficient synthesis of β-amino acid derivatives via asymmetric hydrogenation of unprotected enamines
Hsiao, Yi,Rivera, Nelo R.,Rosner, Thorsten,Krska, Shane W.,Njolito, Eugenia,Wang, Fang,Sun, Yongkui,Armstrong III, Joseph D.,Grabowski, Edward J. J.,Tillyer, Richard D.,Spindler, Felix,Malan, Christophe
, p. 9918 - 9919 (2007/10/03)
A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives β-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required. Copyright
