757951-26-1Relevant academic research and scientific papers
Highly efficient synthesis of β-amino acid derivatives via asymmetric hydrogenation of unprotected enamines
Hsiao, Yi,Rivera, Nelo R.,Rosner, Thorsten,Krska, Shane W.,Njolito, Eugenia,Wang, Fang,Sun, Yongkui,Armstrong III, Joseph D.,Grabowski, Edward J. J.,Tillyer, Richard D.,Spindler, Felix,Malan, Christophe
, p. 9918 - 9919 (2007/10/03)
A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives β-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required. Copyright
