757954-46-4Relevant academic research and scientific papers
Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis
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Page/Page column 10-11, (2010/02/14)
Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phosp
Stereoselective cyclization and pyramidal inversion strategies for P-chirogenic phospholane synthesis
Hoge, Garrett
, p. 9920 - 9921 (2007/10/03)
Preparation of P-chirogenic mono- and bisphospholanes is reported. The demonstrated method employs a stereoselective cyclization of cyclic sulfates with primary phosphines in the presence of base to generate "cis" or "cis/cis" P-chirogenic phospholanes followed by heat-induced pyramidal inversion to provide "trans" or "trans/trans" P-chirogenic phospholanes. A rhodium complex of one "trans/trans" phospholane is applied to the highly enantioselective asymmetric hydrogenation of a substrate precursor to the pharmaceutical candidate pregabalin. Copyright
