757960-70-6Relevant academic research and scientific papers
OPTICALLY ACTIVE ALPHA-AMINOOXYKETONE DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF
-
Page/Page column 13-14; 19, (2008/06/13)
The corresponding α-aminooxy ketone is manufactured with a high yield and a high enantioselectivity. A manufacturing method for an optically active α-aminooxy ketone derivative expressed by formula (1), wherein a ketone expressed by formula (2) is caused
Direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones
Hayashi, Yujiro,Yamaguchi, Junichiro,Sumiya, Tatsunobu,Hibino, Kazuhiro,Shoji, Mitsuru
, p. 5966 - 5973 (2007/10/03)
The direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones has been developed using nitrosobenzene as an oxygen source, affording α-anilinoxy-aldehydes and -ketones with excellent enantioselectivity. Reaction conditions have been optimized, and low temperature (-20 °C) was found to be a key for the successful α-aminoxylation of aldehydes, while slow addition of nitrosobenzene is essential for that of ketones. The scope of the reaction is presented.
