757960-84-2Relevant academic research and scientific papers
Direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones
Hayashi, Yujiro,Yamaguchi, Junichiro,Sumiya, Tatsunobu,Hibino, Kazuhiro,Shoji, Mitsuru
, p. 5966 - 5973 (2007/10/03)
The direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones has been developed using nitrosobenzene as an oxygen source, affording α-anilinoxy-aldehydes and -ketones with excellent enantioselectivity. Reaction conditions have been optimized, and low temperature (-20 °C) was found to be a key for the successful α-aminoxylation of aldehydes, while slow addition of nitrosobenzene is essential for that of ketones. The scope of the reaction is presented.
Direct proline catalyzed asymmetric α-aminooxylation of aldehydes
Hayashi, Yujiro,Yamaguchi, Junichiro,Hibino, Kazuhiro,Shoji, Mitsuru
, p. 8293 - 8296 (2007/10/03)
The direct catalytic enantioselective α-aminooxylation of aldehydes has been developed using nitrosobenzene as the oxygen source and L-proline as catalyst, affording versatile α-aminooxylated aldehydes in high yield with excellent enantioselectivities.
