757967-39-8Relevant academic research and scientific papers
A convenient synthesis of bisamides with BF3 etherate as catalyst
Zhang, Yi,Zhong, Zhihao,Han, Yingmei,Han, Ruirui,Cheng, Xu
supporting information, p. 11080 - 11083 (2014/01/06)
A convenient synthesis of bisamide from aldehyde and amide with BF 3 etherate as catalyst was reported. Both aryl and aliphatic bisamides could be prepared with this procedure in high yield at room temperature and the catalyst loading as low as
Synthesis of enamides from aldehydes and amides
Bayer, Alexander,Maier, Martin E.
, p. 6665 - 6677 (2007/10/03)
A range of double unsaturated amides (15, 19, and 21), obtained by cross-coupling reactions was reacted with aldehydes to hemiaminals. Heating the hemiaminals in the presence of Ac2O and pyridine affected clean conversion to the corresponding enamides, such as 42, 45, and 47. Alternatively, N,S-acetals were prepared which were oxidized to the sulfones. Treatment with base also gave the enamides, favoring the cis-isomer. However, this method is less general. Application of these methods led to the natural products lansiumamide-A (30_cis), lansiumamide-I (31) and lansiumamide-B (32).
