757967-42-3

Basic information

• Product Name: (2E)-N-(1-hydroxy-2-phenylethyl)-3-phenylacrylamide
• Synonyms: (2E)-N-(1-hydroxy-2-phenylethyl)-3-phenylacrylamide
• CAS NO: 757967-42-3
• Molecular Weight: 267.327
• Mol File: 757967-42-3.mol

Chemical Properties

• CAS DataBase Reference: (2E)-N-(1-hydroxy-2-phenylethyl)-3-phenylacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-(1-hydroxy-2-phenylethyl)-3-phenylacrylamide(757967-42-3)
• EPA Substance Registry System: (2E)-N-(1-hydroxy-2-phenylethyl)-3-phenylacrylamide(757967-42-3)

Safety Data

• Hazardous Substances Data: 757967-42-3(Hazardous Substances Data)

Upstream product

• 621-79-4 cinnamamide 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 757967-40-1 (2E)-3-phenyl-N-[2-phenyl-1-(phenylthio)ethyl]acrylamide 
• 757967-41-2 (2E)-3-phenyl-N-[2-phenyl-1-(phenylsulfonyl)ethyl]acrylamide 
• 121817-37-6 (2E)-N-methyl-3-phenyl-N-[(Z)-2-phenylvinyl]acrylamide 
• 121817-36-5 (2E)-3-phenyl-N-[(Z)-2-phenylvinyl]acrylamide 
• 77527-97-0 (2E)-N-methyl-3-phenyl-N-[(E)-2-phenylvinyl]acrylamide 
• 121817-36-5 (2E)-3-phenyl-N-[(E)-2-phenylvinyl]acrylamide 

Relevant articles and documents

Synthesis of enamides from aldehydes and amides

A range of double unsaturated amides (15, 19, and 21), obtained by cross-coupling reactions was reacted with aldehydes to hemiaminals. Heating the hemiaminals in the presence of Ac2O and pyridine affected clean conversion to the corresponding enamides, such as 42, 45, and 47. Alternatively, N,S-acetals were prepared which were oxidized to the sulfones. Treatment with base also gave the enamides, favoring the cis-isomer. However, this method is less general. Application of these methods led to the natural products lansiumamide-A (30_cis), lansiumamide-I (31) and lansiumamide-B (32).