757977-13-2

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 757977-11-0 acetic acid 2-(2-allyloxy-phenyl)-1-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl ester 
• 941672-17-9 4-(2-allyloxy-phenyl)-3-hydroxy-1-(4-methoxy-phenyl)-azetidin-2-one 
• 930785-86-7 4-(2-allyloxy-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one 

Downstream Products

• 757977-21-2 C₄₉H₅₁NO₁₅ 
• 860782-22-5 C₆₄H₈₅NO₁₅Si₂ 
• 757977-19-8 3'-dephenyl-3'-(o-allyloxyphenyl)-4-deacetyl-4-acryloyl-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel 
• 860782-66-7 3'-dephenyl-3'-(o-allyloxyphenyl)-4-deacetyl-4-(pent-4-enoyl)-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel 
• 860782-67-8 3'-dephenyl-3'-(o-allyloxyphenyl)-4-deacetyl-4-(hex-5-enoyl)-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel 
• 860782-68-9 3'-dephenyl-3'-(o-allyloxyphenyl)-4-deacetyl-4-(hept-6-enoyl)-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel 
• 757977-15-4 (3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one 

Relevant academic research and scientific papers

Evaluation of the tubulin-bound paclitaxel conformation: Synthesis, biology, and SAR studies of C-4 to C-3′ bridged paclitaxel analogues

The important anticancer drug paclitaxel binds to the β-subunit of the ββ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of in

CONFORMATIONALLY CONSTRAINED PACLITAXEL ANALOGS AND THEIR USE AS ANTICANCER AND ANTI-ALZHEIMERS AGENTS

Constrained paclitaxel derivatives include a bridge extending from the C-3’ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.