75812-49-6Relevant academic research and scientific papers
Synthesis of 1-D- and 1-L-myo-inosityl 2-N-acetamido-2-deoxy-α-D-glucopyranoside establishes substrate specificity of the Mycobacterium tuberculosis enzyme AcGI deacetylase
Nicholas, Gillian M.,Eckman, Lisa L.,Kovac, Pavol,Otero-Quintero, Sarah,Bewley, Carole A.
, p. 2641 - 2647 (2007/10/03)
Mycothiol (MSH, 1-D-myo-inosityl 2-(N-acetyl-L-cysteinyl)amido-2-deoxy-α-D-glucopyranoside) is the principal low molecular weight thiol in actinomycetes. The enzyme 1-D-myo-inosityl 2-N-acetamido-2-deoxy-α-D-glucopyranoside deacetylase (AcGI deacetylase)
Microbial Products. 5. Absolute Configuration of Aminoglycoside X-14847
Maehr, Hubert,Smallheer, Joanne M.,Blount, John F.
, p. 378 - 381 (2007/10/02)
Analysis of the 1H NMR spectrum of X-14847 nonaacetate reduces the number of possible structures for X-14847 to two.A study involving multiple cuprammonium complexation of the N-acetyl derivative which contains eight hydroxyl groups, generating five vicinal glycol groupings, permits the identification of X-14847 as 2-amino-2-deoxy-α-D-glucopyranosyl-1-O-D-myo-inositol.This assignment is confirmed by single-crystal Roentgen analysis of 2--2-deoxy-α-D-glucopyranosyl-1-O-D-myo-inositol octaacetate prepared from X-14847 with 1-bromo-3-fluoro-4,6-dinitrobenzene and subsequent peracetylation.
