75815-46-2

Basic information

• Product Name: 2-BROMO-1-(2-THIENYL)-1-PROPANONE
• Synonyms: 2-BROMO-1-(2-THIENYL)-1-PROPANONE;1-Propanone, 2-bromo-1-(2-thienyl)- (6CI,9CI);2-(2-Bromo-1-oxopropyl)thiophene;2-Bromo-1-thien-2-ylpropan-1-one;2-(2-Bromopropanoyl)thiophene, 2-(2-Bromo-1-oxoprop-1-yl)thiophene;1-Propanone, 2-broMo-1-(2-thienyl)-;2-BroMo-1-(thiophen-2-yl)propan-1-one
• CAS NO: 75815-46-2
• Molecular Formula: C₇H₇BrOS
• Molecular Weight: 219.1
• Product Categories: ACETYLHALIDE
• Mol File: 75815-46-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 273.897°C at 760 mmHg
• Flash Point: 119.449°C
• Appearance: /
• Density: 1.559g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-1-(2-THIENYL)-1-PROPANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(2-THIENYL)-1-PROPANONE(75815-46-2)
• EPA Substance Registry System: 2-BROMO-1-(2-THIENYL)-1-PROPANONE(75815-46-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 75815-46-2(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(2-THIENYL)-1-PROPANONE is a chemical compound with the molecular formula C8H7BrOS. It is a yellow-brown liquid with a pungent odor and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 2-BROMO-1-(2-THIENYL)-1-PROPANONE is highly reactive and can undergo various chemical reactions such as nucleophilic substitution, oxidation, and reduction. It is also known for its use as a reagent in organic synthesis and as a precursor in the manufacture of fine chemicals. Additionally, it is important to handle this compound with care due to its potential health hazards and should be used in a well-ventilated area with proper protective equipment.

InChI:InChI=1/C7H7BrOS/c1-5(8)7(9)6-3-2-4-10-6/h2-5H,1H3

Upstream product

• 13679-75-9 1-thiophen-2-yl-propan-1-one 

Downstream Products

• 1002756-63-9 3-chloro-6-methyl-5-thiophen-2-yl-4-(2,4,6-trifluoro-phenyl)-pyridazine 
• 4506-74-5 2-morpholino-1-(thiophen-2-yl)propan-1-one 
• 1430402-58-6 C₂₀H₁₉N₅O₂S₂ 
• 1198567-68-8 6-[3-(tert-butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-3-methyl-2-thien-2-ylimidazo[1,2-a]pyridine 
• 1187820-80-9 6-[3-(tert-butyldimethylsilanyloxymethyl)phenyl]-3-methyl-2-thien-2-ylimidazo[1,2-a]pyridine 
• 1126518-86-2 (R)-2-phenyl-1-(thiophen-2-yl)propan-1-one 
• 1126519-27-4 (S)-2-phenyl-1-(thiophen-2-yl)propan-1-one 
• 81590-68-3 5-chloro-1-[1-(2-thenoyl)ethyl]pyrimidin-2-one 

Relevant articles and documents

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp3)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. The reaction efficiently provides highly enantioenrichedN-alkyl sulfoximines (up to 99% yield and >99% ee) featuring secondary benzyl, propargyl, α-carbonyl alkyl, and α-cyano alkyl stereocenters. In addition, we have converted the masked α-chiral primary amines thus obtained to various synthetic building blocks, ligands, and drugs possessing α-chiral N-functionalities, such as carbamate, carboxylamide, secondary and tertiary amine, and oxazoline, with commonly seen α-substitution patterns. These results shine light on the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

Enantioselective and Diastereoselective Construction of Chiral Amino Alcohols by Iridium-f-Amphox-Catalyzed Asymmetric Hydrogenation via Dynamic Kinetic Resolution

The iridium-f-amphox-catalyzed asymmetric hydrogenation of racemic α-amino β-unfunctionalized ketones proceeds via a DKR (dynamic kinetic resolution) process for the construction of various chiral N,N-disubstituted α-amino β-unfunctionalized alcohols in quantitative yields with excellent enantioselectivities and diastereoselectivities (all products >99% ee and >99:1 dr, TON up to 100 000). Importantly, this catalytic asymmetric hydrogenation with a DKR process provided a highly efficient and powerful synthetic strategy for the preparation of key chiral intermediates of the preclinical antitumor agent (S,S)-R116010.

PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX

This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).