75838-24-3

Basic information

• Product Name: 5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL
• Synonyms: 5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL;5-Cyano-1-[3-(trifluoromethyl)phenyl]uracil 97%;5-Cyano-1-[3-(trifluoromethyl)phenyl]uracil97%;2,4-dioxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
• CAS NO: 75838-24-3
• Molecular Formula: C12H6F3N3O2
• Molecular Weight: 281.19
• EINECS: 212-063-3
• Mol File: 75838-24-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 230-233°C
• Appearance: /
• Density: 1.55g/cm³
• Refractive Index: 1.582
• PKA: 6.87±0.10(Predicted)
• CAS DataBase Reference: 5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL(75838-24-3)
• EPA Substance Registry System: 5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL(75838-24-3)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 75838-24-3(Hazardous Substances Data)

Usage

Description

5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL, also known as tifacogin, is a uracil derivative with the molecular formula C11H6F3N3O2. It features a cyano group and a trifluoromethylphenyl group, which contribute to its potential therapeutic properties. Tifacogin has been studied for its use as an anticoagulant and in the treatment of sepsis, with research focusing on its ability to inhibit blood coagulation and reduce mortality in patients with severe sepsis. Additionally, it may have applications in medicinal chemistry for the development of new drugs with enhanced pharmacological properties.

Uses

Used in Pharmaceutical Industry:
5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL is used as an anticoagulant for its ability to inhibit blood coagulation, potentially reducing the risk of blood clots and associated complications.
Used in Sepsis Treatment:
In the field of critical care medicine, 5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL is used as a treatment for sepsis, aiming to reduce mortality in patients with severe sepsis by modulating the body's inflammatory response and improving clinical outcomes.
Used in Medicinal Chemistry Research:
5-CYANO-1-[3-(TRIFLUOROMETHYL)PHENYL]URACIL serves as a compound of interest in medicinal chemistry, where it is used for the development of new drugs with improved pharmacological properties, potentially leading to more effective therapies for various conditions.

InChI:InChI=1/C12H6F3N3O2/c13-12(14,15)8-2-1-3-9(4-8)18-6-7(5-16)10(19)17-11(18)20/h1-4,6H,(H,17,19,20)

Relevant articles and documents

Phenyl uracils

Phenyl uracils, synthesis and intermediates therefor, and compositions for the control of pests, especially fungi and bacteria.